{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_7122307_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"000-876-972-488-669","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8759,"type":"PATENT","title":"University of Columbia","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":13487,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8203,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
Select more for logical Variants
Add to collection
Total patents: more than 10k
Search Applicants and Owners seperately = \"New York Univ\", \"New York University NOT \"state\" NOT \"city\" \", \"Univ New York\", \"NYU\".
Search Applicants and Owners separately: stony brook Uni*; stony brook university. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 13
Searched applicants and Owners= \"Columbia Univ\", \"Univ Columbia\", \" Univ Colum*\", \"Colum* univ\", \"Univ* Colum* NOT British\".
Select more for logical Variants
Add to collection
Total patents: more than 10k
Search Applicants and Owners seperately = \"New York Univ\", \"New York University NOT \"state\" NOT \"city\" \", \"Univ New York\", \"NYU\".
Search Applicants and Owners separately: stony brook Uni*; stony brook university. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 13
(a) contacting a cardiac myocyte in vitro with an amount of a composition comprising a nucleic acid which encodes a HCN channel and MiRP1, effective to cause a sustainable beating rate;\n
(b) measuring the beating rate after step (a);\n
(c) contacting the cardiac myocyte with an agent to be assayed for its effects on the beating rate;\n
(d) measuring the beating rate after step (c); and\n
(e) comparing the difference between step (b) and step (d) thereby determining whether the agent affects the beating rate."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the cardiac myocyte is mammalian."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the composition is introduced into the cell by an adenovirus infection, viral-mediated infection, liposome-mediated transfer, microinjection, electroporation, or by coculturing the cell with the composition."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the HCN is HCN1."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the HCN is HCN2."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the HCN is HCN4."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the HCN channel is HCN2."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the HCN channel is HCN1."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the HCN channel is HCN4."],"number":9,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}