{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"US_6942879_B2","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"125-790-628-029-389","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8901,"type":"PATENT","title":"University of Michigan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":14369,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8216,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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a bundle of semipermeable hollow fibers having an internal surface and an external surface in a chamber defined by a housing, wherein internal surfaces and/or external surfaces of the hollow fibers are coated with:\n
(i) a layer of non-immortalized renal endothelial cells, non-immortalized renal epithelial cells, or a mixture thereof, and\n
(ii) pericytes, vascular smooth muscle cells, or a mixture thereof, wherein\n
the coated hollow fibers are capable of filtering blood when blood is passed through the hollow fibers,\n
opposite ends of the hollow fibers are connected to a blood inlet and a blood outlet, and\n
the housing comprises a filtrate outlet that is in fluid communication with the external surfaces of the hollow fibers."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein internal surfaces of the hollow fibers are coated with (i) and (ii)."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein external surfaces of the hollow fibers are coated with (i) and (ii)."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein internal surfaces and external surfaces of the hollow fibers are coated with (i) and (ii)."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the pericytes, vascular smooth muscle cells, or a mixture thereof (ii) are present in the layer (i)."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the pericytes, vascular smooth muscle cells, or a mixture thereof (ii) are present in a separate layer from the layer (i)."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the layer (i) comprises the renal endothelial cells."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 6, wherein the layer (i) comprises the renal epithelial cells."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 6, wherein the layer (i) comprises a mixture of the renal endothelial cells and the renal epithelial cells."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 6, wherein the layer (i) comprises renal tubule epithelial cells."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the layer (i) also contains the pericytes, vascular smooth muscle cells, or mixture thereof."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the pericytes are mesangial cells."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, which comprises the pericytes."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, which comprises mesangial cells."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, which comprises the vascular smooth muscle cells."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the surfaces of the hollow fibers coated with (i) and (ii) are pre-coated with an extracellular matrix layer."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 16, wherein the extracellular matrix layer contains at least one of Type I collagen, Type IV collagen, laminin, proteoglycan, or fibronectin."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, comprising 100 to 10,000 of the hollow fibers."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 18, wherein the hollow fibers have an ultrafiltration coefficient of greater than 20 mL/hr, Torr, m2."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 18, wherein the hollow fibers have a molecular weight cutoff which is less than 60,000 g/ mol."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 18, wherein the hollow fibers are microporous."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 18, wherein the surfaces of the hollow fibers coated with (i) and (ii) are pre-coated with an extracellular matrix layer."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 19, wherein (ii) are pericytes."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 19, wherein (ii) are mesangial cells."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 19, wherein (ii) are vascular smooth muscle cells."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The bioartifical filtration device of claim 1, wherein the pericytes, vascular smooth muscle cells, or a mixture thereof (ii) are renal cells."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["A method of purifying blood, comprising:\n
passing blood from a subject into the bioartificial filtration device of claim 1, wherein the blood passes through the hollow fibers to produce purified blood, and\n
returning the purified blood to the subject."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the subject is an animal."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the subject is a human."],"number":29,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}