{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"176-484-072-866-329","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"176-484-072-866-329","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10791,"type":"PATENT","title":"The Hebrew University of Jerusalem - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7593,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8259,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"hebrew univ* jerusalem\"; \"hebrew univ* jerus*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1457
Search Applicants and Owners separately: \"hebrew univ* jerusalem\"; \"hebrew univ* jerus*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1457
(i) the weight ratio of the lopinavir to the oil being between 1.5:4 and 1.5:6; and/or;\n
(ii) the core further comprises at least one emulsifier, the weight ratio of the lopinavir to the emulsifier being between 1:1 and 2:1; and/or\n
(iii) the core further comprises at least one emulsifier, the weight ratio of the hydrophobic polymer to the emulsifier being between 2:1 and 4:1; and/or\n
(iv) the weight ratio of the hydrophobic polymer to the oil being at least 3:5."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The delivery system of claim 12, wherein in the nanocapsule the weight ratio of lopinavir to hydrophobic polymer to oil is 1.5:3:5."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["A method of preparing the delivery system of claim 1, comprising:\n
mixing (i) at least one oil and lopinavir with (ii) a solution of a hydrophobic polymer in an organic solvent, optionally in the presence at least one surfactant, the weight ratio of the lopinavir to the hydrophobic polymer being at least 1:1.5, to thereby form an organic phase;\n
adding water to said organic phase under conditions permitting the formation of a suspension of nanocapsules;\n
mixing said suspension of nanocapsules with an aqueous solution of at least one hydrophilic polymer to obtained a mixed suspension; and\n
spray drying the mixed suspension, thereby obtaining said microparticles."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 14, wherein said organic solvent is selected from the group consisting of acetone, methanol, ethanol, isopropanol, ethyl acetate, acetonitrile, and mixtures thereof."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 14, wherein\n
(i) the weight ratio of the lopinavir to the oil being between 1.5:4 and 1.5:6; and/or;\n
(ii) the organic phase further comprises at least one emulsifier, the weight ratio of the lopinavir to the emulsifier being between 1:1 and 2:1; and/or\n
(iii) the organic phase further comprises at least one emulsifier, the weight ratio of the hydrophobic polymer to the emulsifier being between 2:1 and 4:1; and/or\n
(iv) the weight ratio of the hydrophobic polymer to the oil being between at least 3:5; and/or\n
(v) the weight ratio of the hydrophobic polymer to the solvent is between 2:1 and 4:1."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 16, wherein in the weight ratio of lopinavir to hydrophobic polymer to oil to acetone in the organic phase is 1.5:3:5."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 14, wherein the organic phase consists of lopinavir, said hydrophobic polymer, said at least one oil, said solvent and optionally at least one surfactant."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating HIV, comprising administering a therapeutically effective dose of the delivery system of claim 1 to a subject infected by HIV."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the core of the nanoparticle consists of lopinavir and said at least one oil, optionally consisting at least one surfactant."],"number":20,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}